Alaa Kazem , Azad Reza Mansurian , Golam Reza Vaghari , Seyed Mostafa Mir , Fatemeh Mohammadzadeh,
Volume 20, Issue 2 (6-2026)
Background: Diabetic nephropathy is a major cause of kidney failure. The current study aimed to measure serum and urine albumin, as well as other biochemical markers, in individuals with type 2 diabetic nephropathy and to identify rapid diagnostic approaches in these patients.
Methods: This case-control study included 40 patients with diabetic nephropathy and 40 diabetic patients without nephropathy as the control group. Clinical parameters were assessed. After biochemical analysis and based on the ratio of random urine albumin to creatinine, patients were divided into two groups: those without albuminuria and those with microalbuminuria. SPSS version 18 software was used to analyze the results.
Results: In diabetic patients, the levels of urea, creatinine, and uric acid were significantly higher compared with the control group and were 64.68±46.84, 2.01±1.82, and 5.35±2.23, respectively. The average serum albumin content in diabetic patients with nephropathy was notably lower than that in patients without nephropathy (3.74±0.88 and 4.35±0.28, respectively) (p < 0.05). In patients with diabetic nephropathy, urinary albumin had a direct relationship with serum creatinine level (r=0.347, p=0.028). In the control group, serum albumin status could be assessed by measuring creatinine (r = -0.305, p = 0.056), urea (r = -0.333, p = 0.036), and HbA1C (r = -0.376, p = 0.017).
Conclusion: The results of this study revealed that high urinary albumin levels in patients with diabetic nephropathy have a direct association with serum creatinine levels, indicating a useful marker for evaluating nephropathy patients with albuminuria. However, further studies with larger numbers of participants are required.
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